Neutrophil Extracellular Traps (NETs), Microparticles, and Thrombosis in IMHA

Contributions to the body of literature on NETs, both in characterizing them for the first time in dogs and in evaluating their role in canine IMHA, have been made by several Board members, including Drs. Dana LeVine, Unity Jeffery, and Robert Goggs. These publications represent seminal works that fundamentally advance our knowledge of immune-mediated disease and neutrophil biology.

Jeffery, U, Kimura, K, Gray, R, Lueth, P, Bellaire, B and LeVine, D (2015) Dogs cast NETs too: Canine neutrophil extracellular traps in health and immune-mediated hemolytic anemia. Veterinary Immunology and Immunopathology 168: 262-268


Jeffery, U, Ruterbories, L, Hanel, R, LeVine, DN (2017) Cell-Free DNA and DNase Activity in Dogs with Immune-Mediated Hemolytic Anemia.  Journal of Veterinary Internal Medicine 31(5):1441-1450


Goggs, R, Jeffery, U, LeVine, DN and Li, RHL (2020) Neutrophil extracellular traps, cell-free DNA, and immunothrombosis in companion animals: a review. Veterinary Pathology 57: 6-23


Kidd, L, Geddings, J, Hisada, Y, Sueda, M, Concannon, T, Nichols, T, Merricks, E and Mackman, N (2015) Procoagulant microparticles in dogs with immune-mediated hemolytic anemia. Journal of Veterinary Internal Medicine 29(3): 908-916


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