Regulatory T Cells and Myeloid-Derived Suppressor Cells in Dogs and Cats

Three Board members, Drs. Garden, Fogle, and Swann, have contributed to the body of literature on lymphoid and myeloid regulatory cells of dogs and cats. These studies have characterized these cells for the first time in states of health and disease, demonstrating that they share phenotypic and functional characteristics with equivalent murine and human regulatory cells. This research has focused on regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs).

Smithberg, SR, Fogle, JE, Mexas, AM, Reckling, SK, Lankford, SM, Tompkins, MB and Dean, GA (2008) In vivo depletion of CD4+CD25+ regulatory T cells in cats. Journal of Immunological Methods 329(1-2): 81-91


Mexas, AM, Fogle, JE, Tompkins, WA and Tompkins, MB (2008) CD4+CD25+ regulatory T cells are infected and activated during acute FIV infection. Veterinary Immunology Immunopathology 126(3-4): 263-272


Swann JW, Woods K, Wu Y, Glanemann B, Garden OA (2016) Characterisation of the Immunophenotype of Dogs with Primary Immune-Mediated Haemolytic Anaemia. PLoS One 11(12):e0168296


Goulart, MR, Hlavaty, SI, Chang, YM, Polton, G, Stell, A, Perry, J, Wu, Y, Sharma, E, Broxholme, J, Lee, AC, Szladovits, B, Turmaine, M, Gribben, J, Xia, D* and Garden, OA* (2019) Phenotypic and transcriptomic characterization of canine myeloid-derived suppressor cells. Scientific Reports 9(1): 3574; doi: 10.1038/s41598-019-40285-3 (*Dual last authorship)


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