Immune-mediated anemias are caused by a spectrum of disorders that can selectively target erythroid cells in different stages of development, from mature RBCs to erythroid progenitors, resulting in different and distinct constellations of findings that help us diagnose these entities. Treatment and prognosis can be different for different entities, warranting an accurate initial diagnosis. The pathogenesis and laboratory findings for IMHA, PIMA, and PRCA will be discussed, together with a brief discussion of some differential diagnoses.
This seminar will give an overview of our current understanding of the involvement of the GI immune system in diseases including CIE in dogs and cats as well as small cell lymphoma in cats. In addition, opportunities to investigate the innate immune system in the GI tract with the use of organoids will be discussed.
The erythrocyte is uniquely susceptible to oxidative injury for a number of reasons, but namely due to its proximity to oxygen as its main function. Due to this, the RBC has intricate mechanisms to neutralize or reduce this oxidative stress, but in disease states these efforts can be blunted or depleted. This lecture will review the pro- and anti-oxidant balance of the red blood cell, and will discuss the small animal disease states most likely to impact this balance and lead to cellular injury.
This online seminar to delves into the complexities of equine asthma and challenge common perceptions of it as an allergic disease. Dr. Sage provides an overview of the latest insights into the pathophysiology of equine asthma, examining evidence both supporting and opposing the widely accepted type 2 (Th2)-mediated disease hypothesis. The seminar will explore immune mechanisms associated with severe equine asthma, presenting research findings obtained through single-cell RNA sequencing. Attendees can expect a straightforward examination of immune response polarization and a fresh perspective on the disease’s underlying mechanisms. Whether you’re a veterinary professional, researcher, or enthusiast, this seminar offers valuable insights into the evolving landscape of equine respiratory health.
This seminar will focus on the emerging concept of innate immune memory (or trained immunity) in mice, humans, and domestic animals. We will also discuss induction of trained immunity in foals in response to infection with Rhodococcus equi, and limitations of our current model.
This talk will review changes in the immune phenotype in periparturient dairy cattle with a particular focus on regulation of inflammatory response and the interplay with metabolism and nutrition.
Approximately ½ of the dogs from the United States that undergo a renal biopsy for the clinical indication of proteinuria have evidence of immune complex deposition in their glomeruli. Although the incidence of immune complex mediated glomerulonephritis (ICGN) is lower in cats, it can have significant clinical manifestations. This talk will focus on techniques routinely used by the International Veterinary Renal Pathology Service to diagnose ICGN and it will compare and contrast with what is known about and routinely performed for human patients with proteinuria. Specific attention will be given to various diagnostic tests (used in humans) that would be of interest for development and optimization in small animals.
This talk will discuss the molecular mechanisms behind tryptophan metabolism and its impact on the intestinal immune response. Studies pertaining to tryptophan and its metabolites in the pathogenesis of dogs and cats with gastrointestinal disease will also be presented. Finally, the future potential of tryptophan as a therapeutic target in dogs and cats with gastrointestinal disease will be explored.